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However, these results also introduce a practical challenge: the risk of cross-resistance when patients receive more than one ADC with the same payload mechanism

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10.1158/0008-5472.CAN-11-3605 283 Van Der KnaapJ

We see this in regards to reducing the pleasure-seeking around alcohol, nicotine, and potentially sex drives. The evidence surrounding changed sexual function is limited, and mixed

Their concerns were categorized as follows: Overprescribing (clinically inappropriate prescribing): 56% Compromised continuity of care (e.g., follow-up visits, titration, tapering off medication): 50% Lack of complete medical history: 47% Medication interactions and/or side effect management: 43% Lack of transparency to the patients broader care team: 32% Prevalence of compounded GLP-1s/GIPs: 32% Lack of holistic support of weight management: 24% Researchers have raised marketing and safety concerns about compounded and counterfeit GLP-1s, and the FDA recommends that patients "obtain a prescription from their doctor and fill the prescription at a state-licensed pharmacy." However, patient demand for these drugs is likely to persist due to their significantly lower costs